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About Spravato

Spravato is the first FDA-approved nasal spray prescription medicine approved for depression in adults. Spravato works uniquely by targeting the brain’s NMDA receptors. It is used to treat adults with treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions.

How does treatment work?

The nasal spray is administered under the supervision of a clinic health care provider. It is administered in the clinic, and you can expect to be at the clinic for a minimum of two hours. Spravato treatment plans vary based on the recommendations of your healthcare provider. A minimum of 8 weeks is expected for Spravato treatment.

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Treatment Timeline

Weeks 1-4: You’ll be administered SPRAVATO® twice a week for four weeks at the clinic (four hours per week).

Weeks 5-8: You’ll be administered SPRAVATO® once a week for four weeks at the clinic (two hours per week).

Weeks 9+ (Ongoing Maintenance): You’ll be administered SPRAVATO® once every week or once every other week, based on your response.

Spravato Eligibility

Spravato has two medication requirements: 1. You must currently be on ONE oral antidepressant medication. 2. You will need to have tried and failed at least TWO other medications of adequate dose and duration during your current episode.

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Potential Side Effects

Most Common Side Effects

  • Dizziness

  • Nausea

  • Feeling sleepy

  • Spinning sensation

  • Numbness

  • Feeling anxious

  • Lack of energy

  • Increased blood pressure

  • Vomiting

  • Feeling very happy or excited

More Serious Side Effects

  • Feeling sleepy (sedation)

  • Feeling dissociation (disconnected from yourself, your thoughts, feelings, and things around you)

  • Increased risk of suicidal thoughts and behaviors (very rare)

  • Temporary increase in blood pressure that may last about four hours after a dose

  • Problems with thinking clearly

  • Bladder problems (very rare)

Insurance Coverage

Not all insurance companies provide coverage for this treatment. Insurance companies that do provide treatment don’t all have the same coverage plan. This treatment cost is contingent on your specific coverage and is subject to deductibles, copays, etc.




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